IV NAD infusion therapy or the administration of Nicotinamide Adenine Dinucleotide directly into the bloodstream is an exciting and new treatment addressing mental acuity, anti-aging, addiction and physical performance.
Nicotinamide adenine dinucleotide, or NAD+ for short, is a coenzyme found in all living cells. Its function is nothing short of miraculous. However, your NAD+ levels drastically decrease as we age. NAD+ has been proven to repair DNA, protect brain cells, serve as an internal anti-inflammatory, improve mental acuity, curb addiction, fend off neurodegenerative disorders and increase sirtuin levels that help prevent aging.
The Nicotinamide Adenine Ninucleotide (NAD) molecule alternates between two forms. Which one is present depends on how it is being utilized. NAD+ is the reduced (active) form of the molecule. NADH is the oxidized (inactive) form of the same molecule. Energy production in your mitochondria—the little energy factories that pump out ATP—ABSOLUTELY depends on NADH (the inactive form) being recycled back to active NAD+. If this recycling stops and NADH accumulates the cell runs out of energy and slows or even dies. This was clearly shown in a recent study on brain and kidney cells. It goes without saying, then, that depleted levels of NAD+ and accumulation of NADH, or a low ratio of NAD+/NADH, can create problems for your mitochondria and your cells. Indeed, it results in low levels of cellular energy and may be one of the primary contributing factors to “mitochondrial dysfunction”, a condition we now know is implicated in a wide variety of chronic illnesses. Restoring NAD+ levels reverses this process and allows cells to return to full energy status, offering a possible way to undo mitochondrial damage and the resulting chronic illness.
The Role of NAD+ in Mental Acuity, Reversing Chronic Illness and Neurodegenerative Disease
At the end of the day, health and energy production are intimately related. If your mitochondria aren’t functioning or they are producing too little energy, you are going to experience symptoms. When the problem becomes too severe it turns into illness.
The link between NAD+, energy production, and chronic illness really couldn’t be clearer. Low NAD+ results in low ATP levels. Low ATP levels quickly deplete your cell’s energy reserves. Left unchecked, this can lead to cell death. How all of this shows up in your body depends on which cells are being affected. If nerve cells are affected, the lack of energy may manifest itself as depression, anxiety, fatigue and lack of focus.
In severe cases where the nerve cells are dramatically impacted or even die, neurodegenerative illness like Parkinson’s disease and Multiple Sclerosis may manifest themselves. In the worst cases—like mass cellular death—this may lead not only transient symptoms such as tremors, spasms, tingling, numbness and blurred vision, but to permanent, irreversible disability.
If your heart cells are affected, it can lead to cardiovascular disease. If your lung cells are affected pulmonary disorders may present themselves. Basically, when the cells in your organs and tissues don’t have enough energy, illness results. IV NAD+ can be beneficial in restoring energy production—especially in the nerve tissue—and may even prevent permanent damage
NAD+ as an Anti-Aging Molecule
Medical researchers have long known that a group of enzymes called sirtuins play a crucial role in how the body ages—especially SIRT1 and SIRT3. We don’t yet understand precisely how they work, but what we do know is exciting. SIRT enzymes appear to switch off genes that promote aging such as those that cause inflammation, fat synthesis and storage, and blood sugar management issues. Up until now the only way we knew to positively impact these SIRT enzymes was to go on a very low-calorie diet. As uncomfortable as it may be, caloric restriction is one of the few ways that has repeatedly been shown to lead to a longer life. However, the tide appears to be turning. You see, recent research indicates that NAD+ plays a key role in the creation and activation of the sirtuins.
Doctors out of the Department of Developmental Biology at the Washington University School of Medicine were the first to show this link in 2014. The authors note:
“NAD(+) levels decline during the aging process and may be an Achilles’ heel, causing defects in nuclear and mitochondrial functions and resulting in many age-associated pathologies. Restoring NAD(+) by supplementing NAD(+) intermediates can dramatically ameliorate these age-associated functional defects, counteracting many diseases of aging, including neurodegenerative diseases.”
These findings were corroborated in 2016 when the scientific journal Rejuvenation published an article where the authors discussed how low NAD+ levels are DIRECTLY associated with cellular aging, and they emphasized that this process can be prevented by increasing the levels of NAD+ within cells.
So is NAD+ a fountain of youth? It could be. More research needs to be done. But one thing seems clear: It certainly has an impact on your body at the cellular level, and it may just turn back the hands of time.
The role of NAD+ in Exercise and Endurance
It is well known that ATP levels get depleted in muscles while exercising. However, until recently we didn’t know how NAD+ was implicated in this process.
A study done in 2010 using both trained and untrained healthy volunteers helped identify the relationship between NAD+ levels and exercise and endurance. The researchers showed that intense exercise decreases NAD+. When the study participants took an antioxidant supplement containing pycnogenol (which stimulates NAD+ production and protects it from turning into the inactive, oxidized form of the molecule), NAD+ levels increased and exercise performance and “time to fatigue” also improved.
Using a direct IV infusion of NAD+ is certainly a more efficient way of raising NAD+ levels than taking an indirect, oral supplement that acts as a stimulator for NAD+. Thus, IV NAD+ can improve athletic performance, and it likely has a more pronounced effect than oral supplements.
The role of NAD+ in Addiction
One of the newest holistic treatments in the field of addiction recovery is an amino acid therapy, known as NAD+ IV therapy.
Let’s be clear. NAD+ IV Therapy is not a cure for addiction. It’s a natural therapy option that heals the brain on the cellular level and kickstarts recovery. Why is this important? This allows the person struggling with addiction to have a better chance at succeeding with recovery in the long term.
Nicotinamide Adenine Dinucleotide (NAD) is a metabolic co-enzyme and is charged with the important job of structuring, repairing, and remodeling every cell in the body. These specialized enzymes require constant replenishment in the body. Unfortunately, drug and alcohol abuse prompt the human brain to reorganize, particularly on a cellular level. This process, known as neuroadaptation, is directly responsible for addiction-related brain damage and depletion of neurotransmitters. NAD IV therapy is said to replenish the drained enzymes and target brain restoration.
NAD+ IV therapy usually requires one infusion per day for a period of eight to ten days. A facility physician develops an individualized treatment plan for each patient, including the precise NAD+ mixture. At the beginning of each infusion, a trained nurse will insert an IV and begin to slowly infuse the NAD+ mixture. Withdrawal symptoms reportedly begin to subside in just a matter of minutes.
Patients are able to comfortably relax while the formulation is delivered over a period of approximately 2-4 hours. Some reports indicate NAD+ therapy can reduce withdrawal symptoms by 70-80 percent.
Between the fourth and eighth day, patients typically report feeling better, with increased mental clarity. However, it is important to note that patients must complete each infusion process in order to eliminate or minimize cravings. More importantly, after receiving NAD+ IV therapy, each patient must deal with the psychological aspects of addiction, otherwise a relapse is inevitable.
Though NAD+ IV therapy will need additional research and evaluation, the treatment does seem to produce positive results among patients struggling with addiction. Early data seems to indicate the highest success rates with NAD are among alcohol and opiate addicts.
One to two hour infusion ideal for anti-aging, longevity & mental acuity
Two to four hour infusion ideal for brain restoration and addiction management